Effect of pregabalin versus midazolam premedication on the anesthetic and analgesic requirements in pediatric day-case surgery: A randomized controlled trial

Background: This study aimed to compare pregabalin and midazolam premedication in pediatric day-case surgery regarding anesthetic analgesic requirements.Methods: Sixty patients scheduled for were randomly premedicated orally with either (Group P) or M). Intraoperative requirements assessed as primary outcomes. Modified Ramsay Sedation Score (RSS), hemodynamic variables, time eye opening extubation after discontinuation of general anesthesia measured. Post-anesthesia care unit (PACU) duration stay, postoperative Pediatric Anesthesia Emergence Delirium (PAED) scale, Faces Legs Activity Cry Consolability (FLACC) post-operative secondary The was pre-registered at the Pan African Clinical Trials Registry (registration number: PACTR201907535888819; date registration: 22/07/2019).Results: We found no significant differences between studied groups types surgery, preoperative modified RSS, PAED. mean ranks sevoflurane fentanyl consumptions significantly lower group P (p < 0.001). Patients showed means heart rate arterial blood pressure induction anesthesia. Postoperative FLACC pain score a rank P. need rescue analgesics rectal diclofenac meperidine consumption total paracetamol doses comparable both = 0.090). Group stay PACU open extubate, but higher first requirement.Conclusion: Pregabalin reduced perioperative requirements, comparison midazolam; therefore, its use is recommended.